Services
Bioinformatics
Tahoe Bio provides custom bioinformatics solutions for the selection of lead candidates from complex datasets. We have custom pipelines established for the downselection of mAbs using multi-omics data such as 10x single cell RNAseq linked with Mass Spec. We believe in making data accessible and provide reports that are not only intelligible, but actionable as well. Contact us to learn more about how we can customize our pipelines to facilitate your discovery campaign.
Protein engineering
Tahoe Bio combines the latest advances in structural & computational biology to deliver protein engineering solutions. We have a breadth of experience engineering stable antigens for antibody discovery and can work with you to design the optimal set of antigens or subdomains to ensure success. Our expertise in antibody structural engineering can help you take your lead candidates to the next level. We specialize in mAb humanization, alternative mAb backbone design (such as scFv or bispecific construction), developability assessment, and liability reduction.
machine learning and AI solutions
Tahoe Bio is currently developing state of the art machine learning solutions for analyzing and optimizing immunotherapeutic candidates. We’re leveraging our team’s foundation in structural/computational biology to design next generation algorithms. This is an area of active research, but we hope to offer machine learning services in the near future.
F.A.Q.
Tahoe Bioinformatics provides advanced bioinformatics and protein engineering support for immunotherapeutic discovery and development. We specialize in multiomics data analysis, antibody and protein design, and the humanization and optimization of biologic candidates.
We partner with biotechnology and pharmaceutical companies of all sizes—from early-stage startups to established drug developers—who are seeking specialized expertise to accelerate or de-risk their R&D programs.
Our team works as an extension of yours. We can support individual stages—such as data mining, candidate ranking, or structure-guided engineering—or integrate seamlessly across the entire discovery workflow. Our flexible collaboration models ensure minimal disruption to your internal processes.
We combine deep immunology and protein science experience with computational precision. Our dual expertise allows us to interpret data in its biological context, translating complex datasets into actionable insights that directly inform experimental design and decision-making.
We handle a range of multiomics data, including genomics, transcriptomics, proteomics, and single-cell datasets. We’re also experienced with antibody repertoire sequencing and immune profiling data.
Yes. We provide comprehensive antibody engineering services, including sequence analysis, framework selection, humanization, and affinity or stability optimization through both computational and experimental approaches.
We maintain strict data security and confidentiality standards. All projects are governed by NDAs, secure data transfer protocols, and client-approved storage environments.
Our operations are headquartered in the U.S., with collaborators and clients across North America and Europe. Much of our work is conducted remotely using secure digital infrastructure.
You can contact us through our website’s inquiry form. We’ll schedule an introductory meeting to understand your goals, outline deliverables, and tailor a project plan that meets your technical and timeline requirements.